Biochemistry: New Applications
http://www.maplesoft.com/applications/category.aspx?cid=186
en-us2017 Maplesoft, A Division of Waterloo Maple Inc.Maplesoft Document SystemWed, 23 Aug 2017 11:48:03 GMTWed, 23 Aug 2017 11:48:03 GMTNew applications in the Biochemistry categoryhttp://www.mapleprimes.com/images/mapleapps.gifBiochemistry: New Applications
http://www.maplesoft.com/applications/category.aspx?cid=186
Calibrating Response Curves for the Concentration of Melatonin Sulfate in Human Urine
https://www.maplesoft.com/applications/view.aspx?SID=154007&ref=Feed
This application calibrates response curves against data from an immunoassay that records the concentration of melatonin in human urine and its optical density.
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Melatonin is excreted by the pineal gland and regulates human circadian rhythms. Deviations outside of normal boundaries may indicate sleep disorders, depression, schizophrenia, or a range of other conditions.
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Immunoassays typically generate sigmoidal response curves, with upper and lower asymptotes near the infinite and zero analyte concentrations.
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This is accurately described by a four parameter logistic (4-PL) equation. A five parameter logistic equation enables the fitting of asymmetric concentration-response data.<img src="/view.aspx?si=154007/response_curves.png" alt="Calibrating Response Curves for the Concentration of Melatonin Sulfate in Human Urine" align="left"/>This application calibrates response curves against data from an immunoassay that records the concentration of melatonin in human urine and its optical density.
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Melatonin is excreted by the pineal gland and regulates human circadian rhythms. Deviations outside of normal boundaries may indicate sleep disorders, depression, schizophrenia, or a range of other conditions.
<BR><BR>
Immunoassays typically generate sigmoidal response curves, with upper and lower asymptotes near the infinite and zero analyte concentrations.
<BR><BR>
This is accurately described by a four parameter logistic (4-PL) equation. A five parameter logistic equation enables the fitting of asymmetric concentration-response data.154007Wed, 02 Mar 2016 05:00:00 ZSamir KhanSamir KhanCalibrating Response Curves for the Concentration of Melatonin Sulfate in Human Urine
https://www.maplesoft.com/applications/view.aspx?SID=153783&ref=Feed
<p>This application calibrates response curves against data from an immunoassay that records the concentration of melatonin in human urine and its optical density.</p>
<p>Melatonin is excreted by the pineal gland and regulates human circadian rhythms. Deviations outside of normal boundaries may indicate sleep disorders, depression, schizophrenia, or a range of other conditions.</p><img src="/view.aspx?si=153783/melatonin.png" alt="Calibrating Response Curves for the Concentration of Melatonin Sulfate in Human Urine" align="left"/><p>This application calibrates response curves against data from an immunoassay that records the concentration of melatonin in human urine and its optical density.</p>
<p>Melatonin is excreted by the pineal gland and regulates human circadian rhythms. Deviations outside of normal boundaries may indicate sleep disorders, depression, schizophrenia, or a range of other conditions.</p>153783Thu, 09 Apr 2015 04:00:00 ZSamir KhanSamir KhanParameter Estimation for a Chemical Reaction
https://www.maplesoft.com/applications/view.aspx?SID=153782&ref=Feed
<p>This application estimates the rate parameters for a reversible reaction with dimerization of an intermediate. It does this by</p>
<ul>
<li>parameterizing the numerical solution of the different equations that describe the reaction kinetics (with respect to the rate constants)</li>
<li>defining a procedure that calculates the sum of the square of the errors between the model predictions and experimental data,</li>
<li>and minimizing the sum of the square of the errors to find the best fit values of the rate constants</li>
</ul><img src="/view.aspx?si=153782/chemical_kinetics.png" alt="Parameter Estimation for a Chemical Reaction" align="left"/><p>This application estimates the rate parameters for a reversible reaction with dimerization of an intermediate. It does this by</p>
<ul>
<li>parameterizing the numerical solution of the different equations that describe the reaction kinetics (with respect to the rate constants)</li>
<li>defining a procedure that calculates the sum of the square of the errors between the model predictions and experimental data,</li>
<li>and minimizing the sum of the square of the errors to find the best fit values of the rate constants</li>
</ul>153782Thu, 09 Apr 2015 04:00:00 ZSamir KhanSamir KhanQuick- und INR-Werte
https://www.maplesoft.com/applications/view.aspx?SID=121568&ref=Feed
<p>Häufig sind gerinnungshemmende Medikamente erforderlich, z.B. Marcumar nach einer Herzoperation. Quick-Tests nach <em>A.J. QUICK </em>(1894-1978) liefern Ergebnisse, die zur Therapiekontrolle herangezogen werden. Alternativ werden heute INR-Werte (International Ratio) bevorzugt. Eine Umrechnung der Quick-Werte in INR-Werte oder umgekehrt wird im Folgenden diskutiert.</p><img src="/applications/images/app_image_blank_lg.jpg" alt="Quick- und INR-Werte" align="left"/><p>Häufig sind gerinnungshemmende Medikamente erforderlich, z.B. Marcumar nach einer Herzoperation. Quick-Tests nach <em>A.J. QUICK </em>(1894-1978) liefern Ergebnisse, die zur Therapiekontrolle herangezogen werden. Alternativ werden heute INR-Werte (International Ratio) bevorzugt. Eine Umrechnung der Quick-Werte in INR-Werte oder umgekehrt wird im Folgenden diskutiert.</p>121568Sun, 12 Jun 2011 04:00:00 ZProf. Josef BettenProf. Josef BettenRosalind Franklin's X-ray diffraction Photograph of DNA
https://www.maplesoft.com/applications/view.aspx?SID=4902&ref=Feed
In the April 25, 1953 issue of Nature, James D. Watson and Francis H. C. Crick announced one of the most significant scientific discoveries ever: the double helix model for the structure of DNA. They could not have proposed their celebrated structure for DNA without access to experimental results obtained by Rosalind Franklin, particularly this crucial X-ray diffraction photograph taken by her. This worksheet use Maple to show why Franklin's photograph suggests a helix structure.<img src="/view.aspx?si=4902/appviewer.aspx.jpg" alt="Rosalind Franklin's X-ray diffraction Photograph of DNA" align="left"/>In the April 25, 1953 issue of Nature, James D. Watson and Francis H. C. Crick announced one of the most significant scientific discoveries ever: the double helix model for the structure of DNA. They could not have proposed their celebrated structure for DNA without access to experimental results obtained by Rosalind Franklin, particularly this crucial X-ray diffraction photograph taken by her. This worksheet use Maple to show why Franklin's photograph suggests a helix structure.4902Tue, 01 May 2007 00:00:00 ZDr. Frank WangDr. Frank WangProfessional Tips & Techniques: Using Scientific Constants in Maple
https://www.maplesoft.com/applications/view.aspx?SID=1724&ref=Feed
Maple includes an extensive ScientificConstants package that provides access to the values of various constant physical quantities.
Such values can be used to solve equations in fields such as chemistry and physics. The ScientificConstants package also provides the units for each of the constant values, allowing for greater understanding of the equation as well as units matching for error checking of the solution.
The quantities available in the ScientificConstants package are divided into two distinct categories.
1. physical constants
2. properties of the chemical elements (and their isotopes)
This document will highlight the uses of the ScientificConstants package in Maple, and provides some examples of its use.<img src="/view.aspx?si=1724/TTMarApr.jpg" alt="Professional Tips & Techniques: Using Scientific Constants in Maple" align="left"/>Maple includes an extensive ScientificConstants package that provides access to the values of various constant physical quantities.
Such values can be used to solve equations in fields such as chemistry and physics. The ScientificConstants package also provides the units for each of the constant values, allowing for greater understanding of the equation as well as units matching for error checking of the solution.
The quantities available in the ScientificConstants package are divided into two distinct categories.
1. physical constants
2. properties of the chemical elements (and their isotopes)
This document will highlight the uses of the ScientificConstants package in Maple, and provides some examples of its use.1724Mon, 27 Mar 2006 00:00:00 ZMaplesoftMaplesoftThe ScientificConstants Package
https://www.maplesoft.com/applications/view.aspx?SID=4260&ref=Feed
The new ScientificConstants package in Maple 8 provides the values, symbols, uncertainty and units of over 13,000 physical constants. Never again do you have to search the internet or grab a reference book to look up such values. This extensive package gives you access to the basic chemical properties of any element or isotope from the Periodic Table. Also available are 70 physical constants, such as Planck's constant, the Newtonian constant of gravitation, magnetic flux quantum, and speed of light in a vacuum. If a specific physical constant that you need is not included, simply add the constants you commonly use to Maple's database. This flexible package also allows you to modify properties or change the system associated with a constant. The ScientificConstants package in conjunction with the comprehensive Units package introduced in Maple 7 together provide valuable tools for scientists and engineers.<img src="/view.aspx?si=4260//applications/images/app_image_blank_lg.jpg" alt="The ScientificConstants Package" align="left"/>The new ScientificConstants package in Maple 8 provides the values, symbols, uncertainty and units of over 13,000 physical constants. Never again do you have to search the internet or grab a reference book to look up such values. This extensive package gives you access to the basic chemical properties of any element or isotope from the Periodic Table. Also available are 70 physical constants, such as Planck's constant, the Newtonian constant of gravitation, magnetic flux quantum, and speed of light in a vacuum. If a specific physical constant that you need is not included, simply add the constants you commonly use to Maple's database. This flexible package also allows you to modify properties or change the system associated with a constant. The ScientificConstants package in conjunction with the comprehensive Units package introduced in Maple 7 together provide valuable tools for scientists and engineers.4260Mon, 15 Apr 2002 16:08:32 ZMaplesoftMaplesoftDetermination of rate law for enzyme kinetics
https://www.maplesoft.com/applications/view.aspx?SID=3847&ref=Feed
This worksheet demonstrates the use of Maple for determining kinetic rate laws in Biochemical Engineering.<img src="/view.aspx?si=3847//applications/images/app_image_blank_lg.jpg" alt="Determination of rate law for enzyme kinetics " align="left"/>This worksheet demonstrates the use of Maple for determining kinetic rate laws in Biochemical Engineering.3847Wed, 20 Jun 2001 00:00:00 ZRobert GeilRobert GeilMcConnell equations in biochemistry
https://www.maplesoft.com/applications/view.aspx?SID=3848&ref=Feed
This worksheet shows how the McConnell equations, a linear inhomogeneous system of differential equations with constant coefficients, can be solved elegantly by using symbolic matrix algebra only, in particular by using matrix exponentials<img src="/view.aspx?si=3848/448.jpg" alt="McConnell equations in biochemistry" align="left"/>This worksheet shows how the McConnell equations, a linear inhomogeneous system of differential equations with constant coefficients, can be solved elegantly by using symbolic matrix algebra only, in particular by using matrix exponentials3848Wed, 20 Jun 2001 00:00:00 ZJohannes GrotendorstJohannes GrotendorstOptimal control problem in fertilizer economics
https://www.maplesoft.com/applications/view.aspx?SID=3798&ref=Feed
Optimal fertiliser application involves trading off between the costs of buying and spreading fertiliser and the benefits of increased production. This is complicated because fertiliser nutrients carry over in the soil from one year to the next, so that investment in fertiliser in the present contributes a stream of benefit through future years. We are developing a commercial decision support computer application, named Outlook(TM), to assist New Zealand farmers in planning their fertiliser expenditure on a 10-year time horizon. The biological basis for this software is a dynamic nutrient carryover model which predicts the changes in soil nutrient status from year to year under a given application of fertiliser. The original model considered only phosphate dynamics (Metherell et al 1995) and the economic optimisation of that model is described in Woodward (in press). This model is currently being updated to consider the coupled dynamics of both phosphorus and sulphur, the two most important nutrients in New Zealand pastoral farming.<img src="/view.aspx?si=3798//applications/images/app_image_blank_lg.jpg" alt="Optimal control problem in fertilizer economics" align="left"/>Optimal fertiliser application involves trading off between the costs of buying and spreading fertiliser and the benefits of increased production. This is complicated because fertiliser nutrients carry over in the soil from one year to the next, so that investment in fertiliser in the present contributes a stream of benefit through future years. We are developing a commercial decision support computer application, named Outlook(TM), to assist New Zealand farmers in planning their fertiliser expenditure on a 10-year time horizon. The biological basis for this software is a dynamic nutrient carryover model which predicts the changes in soil nutrient status from year to year under a given application of fertiliser. The original model considered only phosphate dynamics (Metherell et al 1995) and the economic optimisation of that model is described in Woodward (in press). This model is currently being updated to consider the coupled dynamics of both phosphorus and sulphur, the two most important nutrients in New Zealand pastoral farming.3798Tue, 19 Jun 2001 00:00:00 ZSimon WoodwardSimon WoodwardApplication of grobner bases to derive steady state rate equations in biochemical kinetic theory
https://www.maplesoft.com/applications/view.aspx?SID=3445&ref=Feed
This worksheet demonstrates the use of Maple, especially its Grobner bases package which mainly depends on Polynomial Ideal Theory, for determining rate equations for both single and multi enzyme systems in Biochemical Kinetic Theory.
<img src="/view.aspx?si=3445//applications/images/app_image_blank_lg.jpg" alt="Application of grobner bases to derive steady state rate equations in biochemical kinetic theory" align="left"/>This worksheet demonstrates the use of Maple, especially its Grobner bases package which mainly depends on Polynomial Ideal Theory, for determining rate equations for both single and multi enzyme systems in Biochemical Kinetic Theory.
3445Mon, 18 Jun 2001 00:00:00 ZNecmettin YildirimNecmettin Yildirim